Vista previa 8 fuera de 13 Tarjetas de estudio
Describe the graph for non-competitive inhibitors
Describe the graph for non-competitive inhibitors
New reset of graph (an eventually plateauing graph) new reset of enzyme substrate complexes.
What is a competitive Inhibitor?
What is a competitive Inhibitor?
A drug-temporary blockage in active site due to inhibitor being similar shape to sububstrate so reduces enzyme substrate complexes but can be overcome by increasing substrate concentration.
Calculation to work out pH?
Calculation to work out pH?
pH=-log[H+]
Describe a graph for rate of reaction against enzyme or substrate concentration ?
Describe a graph for rate of reaction against enzyme or substrate concentration ?
For the increasing part of the graph - positive gradient=where enzyme or substrate concentration is the limiting reactant so directly proportional to rate of reaction. 
Plateau = no longer proportional and starts to plateau as enzymes fully saturated so an increase in substrates doesn't increase rate of reaction(for a rate of reaction vs enzyme concentration graph) 
And when substrates are limiting reactants as enzymes also saturated with as much substrate there is so enzyme substrate complexes are maximum (for rate of reaction vs substrate concentration graph)
Describe the main two components of rate of reaction vs pH graph...
Describe the main two components of rate of reaction vs pH graph...
-At the peak of the graph-Optimum pH-maximum enzyme substrate complexes have formed. 
-As the gradient slopes downwards (on each side) -decrease rate, enzyme looses shape of active site due to breaking of hydrogen &ionic bonds of 3D tertiary structure so less enzyme substrates formed formed due to this chemical disruption. 
-As gradient slopes upward-Increase rate due to reforming/folding /gain of shape of enzymes active site and 3D tertiary structure so more enzyme substrate complexes cab form.
-At the bottom of the graph is where is enzyme is fully denatured and cannot reform.
What is an enzyme and what does it do?
What is an enzyme and what does it do?
A biological catalyst that is recycled with a specific active site due to 3D tertiary structure specifically lowering activation energy required for metabolic reactions.
If an enzyme is phosphorylated why might it be able to bind to its substrate more easily?
If an enzyme is phosphorylated why might it be able to bind to its substrate more easily?
The phosphate group changes the 3D tertiary structure of the enzyme so that it's active site is specific and completementary to the substrate
What does the lock and key model show about enzymes?
What does the lock and key model show about enzymes?
Exact fit to sububstrate , rigid(less moldable) and active site is specifically determined by the 3D tertiary structure