GMS 6504 Study guides, Class notes & Summaries

What are System Independent Parameters? - ANSWER-Affinity Efficacy What are the parts of a system that are identified as System Dependent Parameters? - ANSWER-Number of receptors Cellular machinery Presence of other drugs - Competitive - Noncompetitive Affinity is - ANSWER-Thermokinetic propensity of drug to bind to receptor Based largely on ΔG Efficacy is - ANSWER-Magnitude of change of receptor shape/function upon drug binding Based on atom/atom interactions What i...

GMS 6504 MODULE 1-3 Exam 1 Questions and Answers 100% Pass What are System Independent Parameters? - Answer- Affinity Efficacy What are the parts of a system that are identified as System Dependent Parameters? - Answer- Number of receptors Cellular machinery Presence of other drugs - Competitive - Noncompetitive Affinity is - Answer- Thermokinetic propensity of drug to bind to receptor Based largely on ΔG Efficacy is - Answer- Magnitude of change of receptor shape/function upon drug...

What are System Independent Parameters? - Affinity Efficacy What are the parts of a system that are identified as System Dependent Parameters? - Number of receptors Cellular machinery Presence of other drugs - Competitive - Noncompetitive Affinity is - Thermokinetic propensity of drug to bind to receptor Based largely on ΔG Efficacy is - Magnitude of change of receptor shape/function upon drug bindin

Lipinski's rule of 5 - ANSWER-- Poor absorption or permeation are more likely when: 1. mass greater than 500 Da 2. highly lipophilic - logP > 5 3. more than 5 hydrogen bond donors 4. more than 10 hydrogen bond acceptors Partition coefficient - ANSWER-p = C(octanol)/C(water) - ratio of the equilibrium concentrations of dissolved substance in a two-phase system containing two largely immiscible solvents (water & octanol) - Log10(P) Improved Lipinski Parameters - ANSWER-1. Partition...

What are System Independent Parameters? - ANSWER-Affinity Efficacy What are the parts of a system that are identified as System Dependent Parameters? - ANSWER-Number of receptors Cellular machinery Presence of other drugs - Competitive - Noncompetitive Affinity is - ANSWER-Thermokinetic propensity of drug to bind to receptor Based largely on ΔG Efficacy is - ANSWER-Magnitude of change of receptor shape/function upon drug binding Based on atom/atom interactions What i...

GMS 6504 MODULE 1-3 Exam 1 Questions and Answers 100% Pass What are System Independent Parameters? - Answer- Affinity Efficacy What are the parts of a system that are identified as System Dependent Parameters? - Answer- Number of receptors Cellular machinery Presence of other drugs - Competitive - Noncompetitive Affinity is - Answer- Thermokinetic propensity of drug to bind to receptor Based largely on ΔG Efficacy is - Answer- Magnitude of change of receptor shape/function upon drug...

GMS 6504 MODULE 1-3 Exam 1 Questions and Answers 100% Pass What are System Independent Parameters? - Answer- Affinity Efficacy What are the parts of a system that are identified as System Dependent Parameters? - Answer- Number of receptors Cellular machinery Presence of other drugs - Competitive - Noncompetitive Affinity is - Answer- Thermokinetic propensity of drug to bind to receptor Based largely on ΔG Efficacy is - Answer- Magnitude of change of receptor shape/function upon drug...

GMS 6504 MODULE 1-3 Exam 1 (2024) Questions With Complete

What are System Independent Parameters? - Affinity Efficacy What are the parts of a system that are identified as System Dependent Parameters? - Number of receptors Cellular machinery Presence of other drugs - Competitive - Noncompetitive Affinity is - Thermokinetic propensity of drug to bind to receptor Based largely on ΔG Efficacy is - Magnitude of change of receptor shape/function upon drug binding Based on atom/atom interactions What is the Occupancy Theory? - Re...

GMS 6504 MODULE 1-3 Exam 1 Accurate 100% What are System Independent Parameters? - ANSWER Affinity Efficacy What are the parts of a system that are identified as System Dependent Parameters? - ANSWER Number of receptors Cellular machinery Presence of other drugs - Competitive - Noncompetitive Affinity is - ANSWER Thermokinetic propensity of drug to bind to receptor Based largely on ΔG Efficacy is - ANSWER Magnitude of change of receptor shape/function upon drug binding ...

GMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectLipinski's rule of 5 - ANSWER-- Poor absorption or permeation are more likely when: 1. mass greater than 500 Da 2. highly lipophilic - logP > 5 3. more than 5 hydrogen bond donors 4. more than 10 hydrogen bond acceptors Partition coefficient - ANSWER-p = C(octanol)/C(water) - ratio of the equili...